Soho, W1, located in the centre of London, is contained within the area bounded by Shaftesbury Avenue, Regent Street, Oxford Street (once known as Tiburn Road) and Charing Cross Roads.
Soho is located in the centre of four Underground Stations: Oxford Street, Piccadilly Circus, Leicester Square and Tottenham Court Road. (Tubemap)

The Great Fire in 1666 destroyed most of the City of London, and this neccesitated the building of houses on available land at Soho Fields, which dereived it's name from Charles I's bastard son the Duke of Monmouth who had a habit of bellowing "So-Ho" when hunting or going into battle.

Initially Soho was a fashionable residential area, populated by the wealthy and the famous, such as politicians, churchmen, Dukes and Duchesses. Other residence through the history of Soho included, Wolfgang Amadeus Mozart, Karl Marx, Cassinova, John Constable, and William Blake

Fire again effected the area in the early 1940's, when Soho was bombed during The Blitz. Bombs landed in Old Compton Street, Shaftesbury Avenue and Great Marlborough Street (Which explains the crap archetecture in some areas). During the war, the French House on Dean Street was used as the unofficial headquarters of Charles de Gaulle and his Free French movement.

Other Factoids:

Great Windmill Street used to be a path that crossed Windmill Field to a windmill in which now sits the Windmill Theatre.

Marshall Street is built over a mass graveyard of the victims of the Great Plague in 1665 (More than 150,000 people died of plague between 1603 and 1665).

In 1854, a major outbreak of Cholera occurred. A local doctor, John Snow, determined that the disease was being spread through the water. He had the local water pump in Broadwick Street locked up and the disease dissipated. His name lives on as a pub was named after him (apparently those who drank beer rather than water all survived!)

Great Marlborough Street was named after the victories of the Duke of Marlborough (1650-1722) in the wars of the Spanish Succession (at Blenheim, Ramillies, Oudenaarde, and Malplaquet).

Brewer Street used to be the home to several breweries hence the name.

The Ambassador of Morroco had his head sliced off in Panton Square.